Computational Biology

Project: Binding of agonists and antagonists to G-protein coupled receptors

G-protein coupled receptorsProf. Johan Åqvist
Department of Cell and Molecular Biology, UU

We are using the revolutionary new structures of this class of receptors to explain activation and inhibition mechanisms, in collaboration with the group of Dan Larhammar. Approximately half of the known drugs for humans target such receptors. Therefore, an in-depth understanding of these mechanisms is paramount for progress in drug development.